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Hedgehog(Hh)基因是1980年在果蝇体内发现的体节极性基因,从果蝇到哺乳动物具有较高的保守性。其编码的分泌性信号蛋白对胚胎发育、器官形成具有重要作用[1,2]。脊椎动物胚胎发育的几乎所有步骤都受到了Hh的调控。近几年来,有关Hh及其信号转导通路的研究取得了较多的进展,尤其
Hedgehog (Hh) gene was found in 1980, fruit body in the body of polar genes, from Drosophila to mammals has a high conservation. Its encoded secreted signal protein plays an important role in embryonic development and organ formation [1,2]. Almost all steps of vertebrate embryo development are regulated by Hh. In recent years, more research has been made on Hh and its signal transduction pathways, especially