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目的分析影响凝血酶原时间国际标准化比值(intemational normalized ratio,INR)一致性的因素。方法采用同一台凝血仪，两种不同的凝血酶原时间(PT)试剂，用同一个INR值定标血浆定标后，测定19例健康人、12例长期口服抗凝剂患者、12例初次口服抗凝剂患者和8例长期口服抗凝剂同时用头孢菌素类抗生素抗炎患者的INR值，并对各组测定结果进行统计分析。结果 4组受试者用两种试剂测定的INR值差异均有显著性(P＜0.01)。两种试剂INR值的相差在口服抗凝剂初期比稳定期差异有显著性(P＜0.01)，口服抗凝剂同时用头孢菌素抗炎比单纯口服抗凝剂的INR值差异有显著性(P＜0.01)。结论可能影响INR的一致性的因素有：试剂的来源和敏感性、口服抗凝剂的时期和其他药物的影响。“,”Objective To investigate the factors that influence the consistency of international normalized rarntio (INR) of prothrombin time. Methods Using the same automated blood coagulation analyzer and rnINR calibration plasma with two different types of prothrombin time (PT) reagent to assay the INR rnvalues of 19 controls (group 1), 12 patients who took long-term anticoagulant orally (group 2),12 rnpatients who took it at the first time (group 3) and 8 patients who took long-tern anticoagulant togethrner with cephalosperin N (group 4). Results The two kinds of reagents gave quite different INR valrnues in all four groups (P＜0.01). The INR difference in group 3 (0.23±0.07, n = 12) was rnlarger than that in group 2 (0.51±0.20, n=12) (P＜0.01) .The difference in group 4 rn(0.61 ±0.21, n=8) was larger than that in group 2 ( P＜0.01). Conclusions The factors that may influence INR consistency are the source and sensitivity of the reagents , as well as the period rnof the anticoagulant been taken and the other drugs taken at the same time.