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硫代硫酸钠醇溶液是为临床上用碘酒进行皮肤消毒后脱去碘而配制的外用制剂,又称脱碘酒精。其含量测定按一些《制剂规范》规定,采用直接碘量法,即精密量取本品50 ml,加淀粉指示液1 ml,用碘滴定液(0.1 mol/L)滴定,至溶液显持续的蓝色。但在实际操作中,当滴定终点到达时,并未出现过量碘与淀粉结合而呈现的蓝色,淀粉指示剂失去作用。本文对此进行了研究,发现是因醇的存在,降低了淀粉指示剂的灵敏度。经改进,获得满意结果。现介绍如下。
Sodium thiosulfate alcohol solution for the clinical use of iodine after disinfection of skin iodine and preparation of topical preparations, also known as deiodinated alcohol. Determination of its content by some “preparation specifications” provisions, the use of direct iodometry, the precise amount of this product 50 ml, plus starch indicator solution 1 ml, with iodine titration solution (0.1 mol / L) titration until the solution was significant blue. However, in practice, when the end of the titration was reached, no blue iodine appeared in combination with the starch, and the starch indicator did not work. This article has carried out a study, found that due to the presence of alcohol, reducing the sensitivity of starch indicator. Improved, get satisfactory results. Now introduced as follows.