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目的 :在洲垸型血吸虫病流行区 ,于传播季节观察经常接触疫水人群口服蒿甲醚预防感染血吸虫的效果。方法 :选择 5岁 - 60岁的村民 789人 ,随机配对分为蒿甲醚组 ( 395人 )和对照组 ( 394人 )。预防前 1个月 ,两组人群粪检 ,其血吸虫感染率各为 2 9.5%和 2 9.2 % ,随即用吡喹酮治疗 ,虫卵阳性者 1次顿服 50 mg/ kg,虫卵阴性者顿服 4 0 mg/ kg。蒿甲醚组人群于 6月上旬接触疫水半个月后口服第 1剂蒿甲醚 6mg/ kg,以后每半个月服药 1次 ,共计 9次。对照组人群在上述时间内服安慰剂。两组人群于末次服药后 1个月作粪检 ,评价预防效果。结果 :蒿甲醚组和对照组完成 9次服药和作粪检的分别为 2 90人和 30 5人 ,虫卵阳性率则各为 1.7%和 2 6.9% ,两者间的差别具有显著意义。结论 :在洲垸型血吸虫病流行区 ,口服蒿甲醚可保护人群 ,防止重复感染 ,降低人群的血吸虫感染率。
Objective: To observe the effect of oral administration of artemether against schistosomiasis in the endemic areas of embankment schistosomiasis in the spreading season. Methods: 789 villagers aged 5 to 60 years old were randomly assigned to artemether (395) and control group (394). Pre-prevention 1 month, two groups of fecal semen, the Schistosoma infection rates were 2 9.5% and 2 9.2%, then treated with praziquantel, egg-positive patients with a meal serving 50 mg / kg, egg-negative Dayton service 40 mg / kg. In the artemether group, the first dose of artemether 6 mg / kg was given orally for half a month after the first half of June. After that, the drug was taken once every two weeks for a total of 9 times. The control group was given placebo at these times. Two groups of people in the last administration after 1 month as a fecal examination, evaluation of prevention. Results: The results showed that the positive rate of worm eggs in artemether group and control group were 2 90 and 30 5, respectively, nine times for medication and for stool examination, the positive rate was 1.7% and 6.92% respectively, the difference was significant . Conclusions: Oral administration of artemether in endemic areas of Embankment schistosomiasis can protect people from repeated infections and reduce the infection rate of schistosomiasis in the population.