近年来,选择性抗胆碱药、组胺H_2受体拮抗剂、质子泵抑制剂、粘膜防御药及粘膜血液促进药等抗消化性溃疡药的进展很快。其中组胺H_2受体拮抗剂临床应用约10年,更新了消化性溃疡药物疗法的概念。只要不是严重病症,几乎所有患者均无需住院,在门诊便可得到治疗。然而,约20％的患者对组胺H_2受体拮抗剂显示出抗药性,而且,如果长期用药则导致肝功障碍、抗雄激素作用,及泌乳素增加使女性化乳房出现频度增多等而不得不停药。 In recent years, selective anti-cholinergic drugs, histamine H 2 receptor antagonist, proton pump inhibitors, mucosal defense drugs and mucosal blood promoting drugs such as anti-peptic ulcer progressed rapidly. Histamine H 2 receptor antagonist clinical application of about 10 years, updated the concept of peptic ulcer drug therapy. As long as it is not a serious condition, almost all patients do not need to be hospitalized and can be treated in an outpatient setting. However, about 20% of patients show resistance to histamine H 2 receptor antagonists and, if long-term use leads to liver dysfunction, anti-androgen effects, and increased prolactin increase the frequency of feminized breasts Have to stop medicine.