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目的:了解代谢综合征(MS)患者的代谢紊乱特点,探讨血清脂蛋白酯酶(LPL)含量与MS的内在联系。方法:通过问卷调查、人体测量及生化检查获得腹围(WC)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹胰岛素(INS)、胰岛素敏感指数(ISI)相关数据,纳入MS组24例和健康对照组24例。进行血清LPL(双抗体夹心ELISA法)和游离脂肪酸(FFA)含量的测定(比色法)。结果:(1)病例组WC、SBP、DBP、TGI、NS和FFA显著高于对照组(P<0.01);HDL-CI、SI、血清LPL含量显著低于对照组(血清LPL含量:43.84±4.43ng/mL vs 50.37±4.41ng/mL,P<0.05),而TC、LDL-C和FPG两组之间差别没有统计学意义(P>0.05);(2)血清LPL含量与WC(r=-0.640)、SBP(r=-0.590)、DBP(r=-0.432)、TG(r=-0.784)和FFA(r=-0.720)呈显著负相关(P<0.01);与ISI(r=0.533)、HDL-C(r=0.463)呈显著正相关(P<0.01);而与TC(r=-0.222)和LDL-C(r=-0.213)无明显相关性(P>0.05)。结论:MS患者存在明显的糖、脂代谢紊乱,其血清LPL含量明显降低,FFA水平明显升高,提示LPL可能在MS的发病中起着重要作用,因而可以作为MS的生化标志物之一。
OBJECTIVE: To understand the metabolic disorders in patients with metabolic syndrome (MS) and to explore the intrinsic relationship between serum lipoprotein lipase (LPL) and MS. Methods: WC, SBP, DBP, TG, TC, LDL were measured by questionnaire, anthropometric and biochemical tests. C, HDL-C, INS, and ISI were measured in 24 MS patients and 24 healthy controls. Serum LPL (double antibody sandwich ELISA) and free fatty acid (FFA) content were measured (colorimetric method). Results: (1) The serum levels of HDL-CI, SI and serum LPL were significantly lower than those of the control group (serum LPL content: 43.84 ± 4.43ng / mL vs 50.37 ± 4.41ng / mL, P <0.05), while there was no significant difference between TC, LDL-C and FPG (P> 0.05) = -0.640), SBP (r = -0.590), DBP (r = -0.432), TG (r = -0.784) and FFA (r = -0.720) (P <0.01), but no significant correlation with TC (r = -0.222) and LDL-C (r = -0.213) . CONCLUSIONS: MS patients have obvious disturbance of glucose and lipid metabolism, the serum LPL content is obviously decreased and the FFA level is obviously increased, which suggests that LPL may play an important role in the pathogenesis of MS and thus can be used as one of the biochemical markers of MS.