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目的:研究首次行卵巢肿瘤剥除术后交界性卵巢肿瘤(BOT)患者的生育功能及其转归情况。方法:对43例符合研究条件的BOT患者行问卷调查及对其临床资料进行回顾性分析。结果:43例病人中,浆液性交界性卵巢肿瘤(SBOT)26例,黏液性交界性卵巢肿瘤(MBOT)17例,41例完成问卷调查,中位随访时间63个月。术后无肿瘤复发29例,肿瘤复发14例(死亡2例)。中位复发时间是术后39.3个月。卵巢肿瘤剥除术后肿瘤复发率58%(7/12),而卵巢切除术(根治术)后肿瘤复发率23%(7/31),两者差异比较有统计学意义(P=0.0351),但两者肿瘤复发病死率差异无统计学意义(P>0.05)。术后24例有生育愿望的妇女,12例获得妊娠。结论:卵巢肿瘤剥除术保守手术可作为BOT患者的一种治疗选择,尽管术后肿瘤复发率较高,尤其是行卵巢肿瘤剥除术的病人,但肿瘤复发病死率并未增加;术后有妊娠愿望者有再次妊娠的机会。
Objective: To investigate the fertility and prognosis of the patients with borderline ovarian tumor (BOT) who underwent ovariectomy for the first time. Methods: 43 cases of BOT patients who met the research conditions were surveyed and their clinical data were retrospectively analyzed. Results: Twenty-six cases of serous borderline ovarian tumors (SBOT) and 17 cases of mucinous borderline ovarian tumors (MBOT) were found in 43 patients. Questionnaire was completed in 41 cases with a median follow-up of 63 months. No tumor recurrence in 29 cases, tumor recurrence in 14 cases (2 died). The median time to recurrence was 39.3 months after surgery. The tumor recurrence rate was 58% (7/12) after ovariectomy and 23% (7/31) after ovariectomy (radical operation), the difference was statistically significant (P = 0.0351) , But there was no significant difference in the rates of tumor recurrence between the two groups (P> 0.05). Twenty-four women had postpartum aspirations and 12 had pregnancy. CONCLUSIONS: Conservative surgical resection of ovarian tumors can be used as a treatment option for patients with BOT. Although the recurrence rate of postoperative tumor is high, especially in ovariectomized patients, the mortality of tumor recurrence did not increase. After operation Pregnant aspirants have the opportunity to have another pregnancy.