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目的观察分析舌下含服粉尘螨滴剂治疗儿童呼吸道过敏性疾病的1年期疗效。方法收集2010年1月至2010年8月于首都儿科研究所哮喘中心、顺义妇幼保健院、房山良乡医院等三家医院就诊的哮喘患儿共137例,按患儿监护人意愿,将137例呼吸道过敏性疾病患儿分为观察组85例和对照组52例。其中观察组采用舌下含服粉尘螨滴剂联合基础对症药物治疗的综合方案,对照组仅采用基础对症药物治疗。对2组患者进行为期1年的随访观察,并比较治疗前和治疗3个月、6个月、9个月、12个月后患儿的哮喘日夜间症状评分、鼻部症状评分、药物评分和1年后的哮喘发作次数及自我疗效评价。结果观察组与对照组在治疗1年后,哮喘日夜间症状评分、鼻部症状评分及药物评分均显著减少(P<0.05);组间比较显示,9个月起观察组的哮喘日夜间症状评分、鼻部症状评分均明显低于对照组,差异有统计学意义(P<0.05);且在治疗12个月后,观察组的药物评分、哮喘发作次数及患者自我疗效评价的好转例数比例也均明显低于对照组,差异有统计学意义(P<0.05)。结论综合治疗方案和基础对症药物治疗对儿童呼吸道过敏性疾病症状均有一定疗效,但综合治疗方案的效果比单纯药物更好。
Objective To observe and analyze the one-year efficacy of sublingual dust mite drops in the treatment of respiratory allergic diseases in children. Methods A total of 137 asthmatic children were enrolled in three hospitals including Capital Institute of Pediatrics Asthma Center, Shunyi Maternal and Child Health Hospital and Fangshan Liangxiang Hospital from January 2010 to August 2010. 137 children with respiratory tract Children with allergic diseases were divided into observation group 85 cases and control group 52 cases. The observation group using sublingual dust mite drops combined with basic symptomatic drug treatment of integrated programs, the control group only with basic symptomatic drug treatment. The two groups of patients were followed up for a period of one year. The scores of asthma day-night symptoms, nasal symptom scores, drug scores before treatment, 3 months, 6 months, 9 months and 12 months after treatment were compared. And one year after the number of asthma attacks and self-efficacy evaluation. Results After 1 year of treatment, the symptom scores of asthma day and night, nasal symptom scores and drug scores were significantly decreased in the observation group and the control group (P <0.05). Comparison of the two groups showed that the asthma nighttime symptom Scores of nasal symptoms were significantly lower than the control group, the difference was statistically significant (P <0.05); and after 12 months of treatment, the observation group of drug scores, the number of asthma attacks and self-evaluation of patients improved the number of cases The proportions were also significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Comprehensive treatment programs and basic symptomatic drug treatment have some effect on the symptoms of respiratory allergic diseases in children, but the effect of comprehensive treatment is better than that of simple drugs.