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目的分析血清人绒毛膜促性腺激素(β-hCG)、甲胎蛋白(AFP)、非结合雌三醇(uE_3)水平与妊娠期并发症及分娩结局的关系。方法以2014年3月-2015年3月在该院进行产前检查,孕中期进行血清β-hCG、AFP、uE_3水平检测,并在该院住院分娩的产妇为观察对象,根据血清β-hCG、AFP、uE_3的MoM值分为正常组、过高组和降低组。比较β-hCG、AFP、uE_3正常组、升高组和降低组妊娠并发症和不良分娩结局的发生率。结果血清AFP水平过高组发生妊娠期高血压、妊娠期糖尿病和胎盘早剥以及早产的例数明显多于正常组,差别具有统计学意义(P<0.05);血清β-hCG过高组和uE_3降低组产妇发生妊娠期高血压、妊娠期糖尿病和胎盘早剥的例数明显多于正常组,且早产和产后出血的发生率也较正常组高,差异有统计学意义(P<0.05)。结论高水平的β-hCG、AFP和低水平的uE_3与妊娠期并发症和不良分娩结局的发生密切相关。
Objective To analyze the relationship between serum levels of human chorionic gonadotropin (β-hCG), alpha-fetoprotein (AFP), unconjugated estriol (uE_3) and gestational complications and delivery outcomes. Methods From March 2014 to March 2015, prenatal examination was performed in this hospital. Serum levels of β-hCG, AFP and uE_3 were detected in the second trimester of pregnancy. Obstetric women were hospitalized in this hospital. According to serum β-hCG , AFP, uE_3 MoM value is divided into normal group, over-high group and reduce the group. Compare the β-hCG, AFP, uE_3 normal group, elevated group and reduce the incidence of pregnancy complications and adverse delivery outcomes. Results The incidence of gestational hypertension, gestational diabetes mellitus and placental abruption as well as preterm birth were significantly higher in the serum AFP level group than in the normal group (P <0.05). Serum β-hCG over-high group The incidence of gestational hypertension, gestational diabetes mellitus and placental abruption in uE_3 group was significantly higher than that in normal group, and the incidence of preterm and postpartum hemorrhage was also higher than that in normal group (P <0.05) . Conclusion High level of β-hCG, AFP and low level of uE_3 are closely related to the occurrence of complications and poor delivery in pregnancy.