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目的分析临床常见检测指标在糖尿病慢性肾脏疾病(CKD)诊断中应用的价值。方法选取T2DM患者78例,根据UAER结果将患者分为单纯T2DM组、早期CKD组(20μg/min≤UAER<200/μg/min)和临床期CKD组(UAER≥200μg/min),比较各组临床指标。结果 Logisitc回归分析显示,转铁蛋白(TF)、TC、Scr、SUA、BMI、SBP为CKD发生的危险因素;受试者工作特征(ROC)曲线分析显示,TF和TC联合诊断有较大的诊断价值(AUC=0.959);判别分析得到TF、TC、SBP、GFR为筛选后指标在早期CKD组和临床期CKD组分类正确率为87.2%。结论 TF、TC、Scr、SUA、BMI、SBP为CKD的危险因素,综合简便性及诊断价值,TF与TC联合诊断价值较高;以此常见指标建立的判别函数对CKD的诊断有一定的参考价值。
Objective To analyze the clinical value of common detection indexes in the diagnosis of chronic kidney disease (CKD) in diabetes. Methods Totally 78 patients with T2DM were enrolled in this study. According to UAER results, patients were divided into three groups: the simple T2DM group, the early CKD group (20μg / min≤UAER <200 / μg / min) and the clinical CKD group (UAER≥200μg / min) Clinical indicators. Results Logistic regression analysis showed that TF, TC, Scr, SUA, BMI and SBP were the risk factors of CKD. ROC curve analysis showed that the combination of TF and TC had a greater Diagnostic value (AUC = 0.959); discriminant analysis of TF, TC, SBP, GFR screening index for the early CKD group and clinical CKD group, the correct rate was 87.2%. Conclusions TF, TC, Scr, SUA, BMI and SBP are the risk factors of CKD. The comprehensiveness and diagnostic value of TF, TC and TC are of high diagnostic value. The discriminant functions established by these common indexes have certain reference to the diagnosis of CKD value.