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目的:了解该院卵巢癌患者的临床病理特点、诊治及愈后,以期提高对该病的进一步认识。方法:回顾性分析80例卵巢癌患者的临床病例资料及诊治情况。结果:80例患者平均年龄55.3岁,腹痛伴腹胀44例,盆腔包块36例,病理分型中浆液性囊腺癌48例(60.0%),黏液性囊腺癌10例(12.5%),子宫内膜样癌2例(2.5%),其他20例(25.0%)。CA125、CA153在晚期患者明显升高,与早期比较有统计学差异(P<0.01)。CA125在浆液性囊腺癌中的表达明显高于其他组别(P<0.01)。不同临床分期患者的2年和5年生存率比较,差异有统计学意义(P<0.01)。结论:卵巢癌以腹胀、腹痛为主要临床表现,但无特异性,定期妇科影像学检查可能有助于发现早期肿瘤。肿瘤标记物在晚期患者升高明显,CA125可能有助于发现早期肿瘤。手术治疗为主,综合治疗为辅,早期发现卵巢癌是愈后好的关键。
Objective: To understand the clinicopathological characteristics of ovarian cancer patients, diagnosis and treatment and prognosis, in order to improve the further understanding of the disease. Methods: A retrospective analysis of 80 cases of ovarian cancer in patients with clinical data and diagnosis and treatment. Results: The average age of 80 patients was 55.3 years old, abdominal pain with abdominal distension in 44 cases, pelvic mass in 36 cases, pathological type of serous cystadenocarcinoma in 48 cases (60.0%), mucinous cystadenocarcinoma in 10 cases (12.5%), Endometrioid carcinoma in 2 cases (2.5%), the other 20 cases (25.0%). The levels of CA125 and CA153 in patients with advanced stage were significantly higher than those in early stage (P <0.01). The expression of CA125 in serous cystadenocarcinoma was significantly higher than other groups (P <0.01). The difference of 2-year and 5-year survival rates of patients with different clinical stage was statistically significant (P <0.01). Conclusion: Ovarian cancer is the main clinical manifestations of abdominal distension and abdominal pain, but no specific, regular gynecological imaging may help find early tumors. Tumor markers increase significantly in patients with advanced disease, CA125 may help find early tumors. Surgical treatment, supplemented by comprehensive treatment, early detection of ovarian cancer is the key to better prognosis.