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合成和鉴定了十六种新的含卤根的氨基酸乙酯的二价铂配合物。其中八种含碘配合物[PtA_2I_2](A=DL-α-AlaOEt,L-α-AlaOEt,DL-α-PheOEt,L-α-PheOEt,DL-α-AspOEt,L-α-AspOEt,DL-α-SerOEt)和[PtAI_2](A=L-α-LysOEt)以及部分含氯配合物[PtA_2Cl_2](A=DL-α-PheOEt,DL-α-ASpOEt,L-α-AspOEt)和(DL-α-PheHOEt)_2[PtCl_4]由K_2[PtX_4](X=I~-,Cl~-)与相应酯在水中作用而得。易水解的其它含氯氨基酸乙酯配合物[PtA_2Cl_2](A=DL-α-AlaOEt,L-α-AlaOEt,L-α-pheOEt,DL-α-serOEt)通过相应的含碘配合物[PtA_2I_2]与AgCl在非水体系(丙酮)中交换而成。摩尔电导率表明,除(DL-α-pheHOEt)_2[PtCl_4]外,所得配合物均为电中性。分子偶极矩测定和改良的硫脲反应确定了七种含碘配合物:三种含氯配合物[Pt(L-α-AlaOEt)_2Cl_2],[Pt(DL-α-AlaOEt)_2Cl_2]和[Pt(DL-α-SerOEt)_2Cl_2]为顺式构型,其余四种为反式构型的含氯苯丙氨酸乙酯或含氯天冬氨酸乙酯配合物。对决定配合物构型的主要因素进行了讨论。
Sixteen novel divalent platinum complexes of amino-containing ethyl esters containing halides were synthesized and characterized. Eight iodine-containing complexes [PtA_2I_2] (A = DL-α-AlaOEt, L-α-AlaOEt, DL-α-PheOEt, L-α-PheOEt, DL-α-AspOEt, (A = DL-α-PheOEt, DL-α-SerOEt) and [PtAI_2] (A = L-α-LysOEt) and some chlorine-containing complexes [PtA_2Cl_2] DL-α-PheHOEt) _2 [PtCl_4] by K_2 [PtX_4] (X = I ~ -, Cl ~ -) with the corresponding ester role in the water derived. Other hydrolysable ethyl chloroacetate complexes [PtA_2Cl_2] (A = DL-α-AlaOEt, L-α-AlaOEt, L-α-pheOEt, DL-α-serOEt) ] With AgCl in a non-aqueous system (acetone). The molar conductivity showed that all the complexes except for (DL-α-pheHOEt) _2 [PtCl_4] were electrically neutral. Seven kinds of iodine-containing complexes were identified by molecular dipole moment measurement and modified thiourea reaction: three kinds of chlorine-containing complexes [Pt (L-α-AlaOEt) _2Cl_2], [Pt (DL-α-AlaOEt) _2Cl_2] [Pt (DL-α-SerOEt) _2Cl_2] is a cis configuration, and the remaining four are chloro-phenylalanine ethyl ester or chlorine-containing aspartate complexes in the trans configuration. The main determinants of the complex configuration are discussed.