Objective:To evaluate whether garlicin can prevent reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction(AMI).Methods:Twenty-two male Chinese mini swines were randomized into 3 groups:sham-operation group(n=6),control group(n=8),and garlicin group(n=8).The distal part of left anterior descending coronary artery(LAD)in swines of the latter two groups was completely occluded by dilated balloon for 2 h and a successful AMI model was confirmed by coronary angiography(CAG)and electrocardiograph(ECG),which was then reperfused for 3 h.In the sham-operation group,balloon was placed in LAD without dilatation.Garlicin at a dosage of 1.88 mg/kg was injected 10 min before LAD occlusion until reperfusion for 1 h in the garlicin group.To assess serial cardiac function,hemodynamic data were examined by catheter method before AMI,2 h after occlusion and 1,2,and 3 h after reperfusion.Myocardial contrast echocardiography(MCE)and double staining with Evans blue and thioflavin-S were performed to evaluate myocardial no-reflow area(NRA)and risk area(RA).Results:Left ventricular systolic pressure and left ventricular end-diastolic pressure significantly improved in the garlicin group after reperfusion compared with the control group(P<0.05)and 2 h after AMI(P<0.05).MCE showed garlicin decreased reperfusion NRA after AMI compared with the control group(P<0.05).In double staining,NRA/RA in the garlicin group was 18.78%,significantly lower than that of the control group(49.84%,P<0.01).Conclustions:Gariicin has a preventive effect on the porcine model of myocardial infarction reperfusion no-reflow by improving hemodynamics and decreasing NRA. Objective: To evaluate whether garlicin can prevent reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI). Methods: Twenty-two male Chinese mini swines were randomized into 3 groups: sham-operation group ), control group (n = 8), and garlicin group (n = 8). The distal part of anterior descending coronary artery (LAD) in swines of the latter two groups were completely occluded by dilated balloon for 2 h and a successful AMI model was confirmed by coronary angiography (CAG) and electrocardiograph (ECG), which was then reperfused for 3 h. In the sham-operation group, balloon was placed in LAD without dilatation. Garlicin at a dosage of 1.88 mg / kg was injected 10 min before LAD occlusion until reperfusion for 1 h in the garlicin group. To assess serial cardiac function, hemodynamic data were examined by catheter method before AMI, 2 h after occlusion and 1,2, and 3 h after reperfusion. Myocardial contrast echocardiography ( MCE) and double staining with Evans blue and thiofl avin-S were performed to evaluate myocardial no-reflow area (NRA) and risk area (RA) .Results: Left ventricular systolic pressure and left ventricular end-diastolic pressure significantly improved in the garlicin group after reperfusion compared with the control group (P <0.05) and 2 h after AMI (P <0.05) .MCE showed garlicin decreased reperfusion NRA after AMI compared with the control group (P <0.05) .In double staining, NRA / RA in the garlicin group was 18.78%, obviously lower than that of the control group (49.84%, P <0.01) .Conclustions: Gariicin has a preventive effect on the porcine model of myocardial infarction reperfusion no-reflow by improving hemodynamics and decreasing NRA.