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本文对16例(23例次)小脑与脊髓小脑共济失调应用胞二磷胆碱或水相酸毒扁豆碱进行实验治疗,分析疗效与病程及家族史的关系,并对其可能的作用机制进行讨论。 临床资料 16例中40岁以下者3例,40—50岁8例,51—60岁5例。男9例,女7例。有家族史9例。病程为1—16年,平均病程5.5年,其中病程1—3年者7例,5—16年者9例。全部病例均有共济失调及语言障碍。有智力减退者10例,吞咽呛咳9例,眼球联合运动不全8例,头颤动3例。全部腱反射均活跃。深感觉减退11例。有病理征者6例。 诊断标准及分型 诊断标准1.临床具有缓慢进展的小脑或脊髓小脑共济失调病征。2.腰椎穿刺均无压力及成份异常。3.全部病例均进行非强化CT扫描,仅选用CT显示小脑、脑干萎缩或正常的病例。有严
In this paper, 16 cases (23 cases) of cerebella and spinocerebellar ataxia with citicoline or water phase acid physostigmine experimental treatment, analysis of efficacy and duration of disease and family history, and its possible mechanism of action have a discussion. Clinical data of 16 cases of 40 years of age in 3 cases, 40-50 years old in 8 cases, 51-60 years in 5 cases. 9 males and 7 females. Family history in 9 cases. The duration of disease ranged from 1 to 16 years with an average duration of 5.5 years, of which 7 were 1-3 years and 9-5-16 years. All cases were ataxia and language disorders. There are 10 cases of mental retardation, swallowing cough in 9 cases, ocular uncoordinated in 8 cases, 3 cases of head fibrillation. All tendon reflexes are active. Deep feeling diminished in 11 cases. 6 cases of pathological sign. Diagnostic criteria and classification of diagnostic criteria 1. Clinical slow progress of cerebellar or spinocerebellar ataxia symptoms. 2. Lumbar puncture pressure and composition are not abnormal. 3. All cases were non-enhanced CT scan, only the use of CT showed cerebellum, brainstem atrophy or normal cases. There are strict