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背景与目的:探讨乌鲁木齐地区人群中载脂蛋白E(ApoE)基因多态性与帕金森病(Parkinson’s disease,PD)的相关性。材料与方法:用PCR-RFLP方法检测51例散发性PD和52例正常对照的ApoE基因型。根据有无痴呆将所有PD患者分为二组,即PDD组和PI)组。用X2检验进行关联分析。结果:PD+PDD组、PD组和PDD组与对照组间的ApoE基因型频率差异无显著性(P>0.05)。PD组ApoE等位基因频率与对照组相近。PD+PDD组和PDD组的ε2和ε3频率类似于对照组,但是,ε4频率(分别为12.8％和16.7％)明显高于正常对照组(3.9％),组间比较差异有显著性(P<0.05)。结论:ApoEε4等位基因对PD的发生无明显影响,但是,它是伴有PD的痴呆患者的发病危险因素。
BACKGROUND & AIM: To investigate the association between apolipoprotein E (ApoE) gene polymorphisms and Parkinson’s disease (PD) in Urumqi population. MATERIALS AND METHODS: ApoE genotypes of 51 cases of sporadic PD and 52 cases of normal controls were detected by PCR-RFLP. All patients with PD were divided into two groups based on presence or absence of dementia, PDD group and PI group. X2 test for correlation analysis. Results: There was no significant difference in the frequency of ApoE genotype between PD + PDD group, PD group and PDD group and control group (P> 0.05). The frequency of ApoE allele in PD group was similar to that in control group. The frequencies of ε2 and ε3 in PD + PDD group and PDD group were similar to those in control group, however, the frequencies of ε4 (12.8% and 16.7%, respectively) were significantly higher than those in normal control group (3.9%) <0.05). Conclusion: ApoEε4 allele has no obvious effect on the occurrence of PD, however, it is a risk factor for the pathogenesis of dementia with PD.