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哮喘发病具有明显的遗传倾向 ,国外研究显示α1 抗糜蛋白酶 (α1 ＡＣＴ)遗传缺陷是哮喘发病的重要因素[1] 。为探讨α1 抗糜蛋白酶遗传缺陷在中国儿童哮喘发病中的作用 ,本研究对90例重庆市汉族儿童哮喘血浆α1 ＡＣＴ含量、Ｂｏｎｎ 1和Ｂｏｃｈｕｍ 1变异体进行了初步探讨 ,
Asthma incidence has obvious genetic predisposition, foreign studies have shown that α1 anti-chymotrypsin (α1 ACT) genetic defect is an important factor in the pathogenesis of asthma [1]. In order to investigate the role of α1 chymotrypsin genetic defects in the pathogenesis of asthma in children in China, 90 plasma levels of α1-ACT, Bonn 1 and Bochum 1 variants in asthmatic children were detected in 90 Chinese Han children.