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目的：本文对３０例围绝经期功能性子宫出血用露特尼治疗，以观察其临床疗效。方法：患者自月经周期ｄ１５至ｄ２４服露特尼５ｍｇ／ｄ，撤退出血ｄ１５起重复，共４个周期。结果：治疗后患者均可按时出血，出血天数由（１２．１±１１．１）ｄ减少至（６．２±２．１）ｄ（Ｐ＜０．０５），经量过多及经期延长者１４例（４６．７％）及１６例（５３．３％）分别减少至３例（１０．０％）及０（Ｐ＜０．００１）。治疗后增殖期子宫内膜由１９例（６３．３％）明显减少至９例（３１．０％），分泌期内膜由５例（１６．１％）增加至１８例（６２．１％）（Ｐ＜０．０５），且有３例内膜单纯增生患者在治疗后增生消失。血糖代谢无明显改变，ＨＤＣＣ降低（１．３±０．３→１．２±０．２Ｐ＜０．０５）较为明显。临床耐受性高。结论：对围绝经期功能性子宫出血患者及需长期孕激素治疗患者，可选用露特尼治疗。
Objective: In this paper, 30 cases of climacteric dysfunctional uterine bleeding with rutinib treatment to observe its clinical efficacy. Methods: Patients from the menstrual cycle d15 to d24 service lutetium 5mg / d, retreat bleeding d15 repeat, a total of 4 cycles. Results: All the patients were able to hemorrhage on time, the number of bleeding days decreased from (12.1 ± 11.1) d to (6.2 ± 2.1) d (P <0.05) 14 (46.7%) and 16 (53.3%) patients were reduced to 3 (10.0%) and 0 (P <0.001) respectively. Endometrium proliferative phase decreased significantly from 19 cases (63.3%) to 9 cases (31.0%) during proliferative stage and increased from 5 cases (16.1%) to 18 cases (62.1% ) (P <0.05), and 3 patients with endometrial hyperplasia disappeared after treatment. No significant changes in blood glucose metabolism, HDC C decreased (1.3 ± 0.3 → 1.2 ± 0.2P <0.05) is more obvious. High clinical tolerance. CONCLUSIONS: Lutetium may be used in patients with functional uterine bleeding during peri-menopausal period and long-term progestin therapy.