论文部分内容阅读
目的探讨TNF-α和IL-6水平与冠心病不同表型以及冠状动脉病变程度之间的关系。方法应用酶联免疫双抗体夹心法(ELISA)测定57例冠心病患者(其中急性心肌梗死30例、不稳定型心绞痛13例、稳定型心绞痛14例)和23例正常对照组的血清TNF-α和IL-6水平。所有急性心肌梗死患者,心绞痛患者和正常对照者均行冠状动脉造影。结果 AMI组和UAP组TNF-α水平明显高于对照组(P<0.05);AMI组和UAP组IL-6水平均显著高于对照组和SAP组(P<0.05,P<0.01)。TNF-α水平与IL-6成正相关(r=0.271,P=0.042)。中度狭窄组和重度狭窄组TNF-α水平明显高于对照组和轻度狭窄组(P<0.05);IL-6水平重度组和中度组明显高于对照组(P<0.01,P<0.05),并且两组均高于轻度组(P<0.05)。结论高水平的TNF-α和IL-6可能与冠状动脉粥样斑块的发生发展与稳定性密切相关,特别是在急性冠状动脉综合征(ACS)的发生过程中扮演重要角色。
Objective To investigate the relationship between TNF-α and IL-6 levels and the different phenotypes of coronary heart disease and the severity of coronary artery disease. Methods Serum levels of TNF-α in 57 patients with coronary heart disease (30 acute myocardial infarction, 13 unstable angina pectoris and 14 stable angina pectoris) and 23 normal controls were measured by enzyme-linked immunosorbent assay (ELISA) And IL-6 levels. All patients with acute myocardial infarction, angina patients and normal controls underwent coronary angiography. Results The levels of TNF-α in AMI group and UAP group were significantly higher than those in control group (P <0.05). The levels of IL-6 in AMI group and UAP group were significantly higher than those in control group and SAP group (P <0.05, P <0.01). The level of TNF-α was positively correlated with IL-6 (r = 0.271, P = 0.042). The levels of TNF-α in moderate and severe stenosis group were significantly higher than those in control group and mild stenosis group (P <0.05). The levels of IL-6 in severe and moderate stenosis group were significantly higher than those in control group (P <0.01, P < 0.05), and both groups were higher than mild group (P <0.05). Conclusions High levels of TNF-α and IL-6 may be closely related to the development and stability of atherosclerotic plaque. Especially, they play an important role in the development of acute coronary syndrome (ACS).