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目的:分析总结1989~2013年国内、外公开发表以及我院收治自发性卵巢过度刺激综合征(sOHSS)患者的临床资料及诊疗特点。方法:分别以“自发性卵巢过度刺激”和“spontaneous ovarian hyperstimulation syndrome”为检索词,检索1989~2013年期间公开发表文献,并结合我院诊治的1例患者进行文献复习并综述。结果:sOHSS多发生于妊娠早、中时期,以孕6~16周发病率最高,中位数孕周为10周;病史中无药物诱发促排卵史,临床症状主要表现为腹痛腹胀、恶心呕吐、胸腹水、全身水肿,血液生化检查提示血液浓缩、血清离子紊乱、血清激素水平不同程度上升;超声表现为双侧卵巢呈多囊性外凸性增大;治疗方式以缓解症状为主的对症治疗为原则。结论:应提高对sOHSS的认识,并注意与妊娠合并卵巢肿瘤相鉴别,早期诊断后尽早实施以预防及对症为主的综合治疗策略,避免过度治疗。
OBJECTIVE: To analyze and summarize the clinical data and diagnosis and treatment of patients with spontaneous ovarian hyperstimulation syndrome (sOHSS) published in our country from 1989 to 2013 and published in our hospital. METHODS: The articles published in the period of 1989 ~ 2013 were searched with the words “spontaneous ovarian hyperstimulation syndrome” and “spontaneous ovarian hyperstimulation syndrome” respectively, and one case of patients treated in our hospital was reviewed and reviewed . Results: The incidence of sOHSS occurred mostly in the first and third trimester of pregnancy, with the highest incidence of 6 ~ 16 weeks’ gestation and the median gestational age of 10 weeks. No history of drug induced ovulation induction was found. The clinical manifestations were mainly abdominal distension, nausea and vomiting , Pleural effusion, systemic edema, blood biochemical tests suggest that blood concentration, serum ion disorders, serum hormone levels rise to varying degrees; ultrasound showed bilateral ovarian polycystic ovary increased convex; treatment to alleviate the symptoms of symptomatic The principle of treatment. Conclusion: It is necessary to improve the understanding of sOHSS, and pay attention to the identification of pregnancy with ovarian cancer phase, as soon as possible after the early diagnosis of the implementation of comprehensive preventive and symptomatic treatment strategies to avoid over-treatment.