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树突状细胞 (DC)是体内最有效的抗原提呈细胞 ,可以将抗原提呈给T淋巴细胞 ,诱生抗原特异性CTL ,在免疫反应中发挥重要作用 .活性氧 (ROS)、自由基 (RF)是体内一系列重要的生物活性分子 ,大量研究表明ROS参与包括NF κB在内的多种信号途径 ,诱导重要的免疫系统基因的表达 .氧化应激诱导树突状细胞几种与T细胞相互作用的表面标志分子的表达上调 ,包括MHCⅡ类分子 (DR和DQ)及共刺激分子CD4 0、CD80和CD86 ,并通过下调由甘露糖受体介导的胞饮作用来诱导DC早期成熟 .另外ROS处理过的DC比正常细胞更能刺激T淋巴细胞增殖 ,此作用可以被自由基清除剂N 乙酰半胱氨酸 (NAC)和别嘌呤醇抑制 .本文就ROS对树突细胞表型和功能成熟作用的研究进展予以综述
Dendritic cells (DCs) are the most effective antigen-presenting cells in the body and can present antigens to T lymphocytes and induce antigen-specific CTLs, playing an important role in immune responses. Reactive oxygen species (ROS), free radicals (RF) is a series of important bioactive molecules in the body, a large number of studies have shown that ROS involved in a variety of signaling pathways including NF κB, induced the expression of important immune system genes.Oxidative stress induced dendritic cells and T Up-regulation of cell-surface marker molecules including MHC class II molecules (DR and DQ) and co-stimulatory molecules CD4 0, CD80 and CD86 and induction of early maturation of DCs by downregulation of mannose receptor-mediated pinocytosis .In addition, ROS-treated DC stimulated the proliferation of T lymphocytes more than normal cells, which can be inhibited by the free radical scavengers NAC and allopurinol.In this paper, the effects of ROS on dendritic cell phenotype And the research progress of function maturation