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目的：观察氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的疗效和安全性。方法：72例单疱病毒性角膜炎患者随机均分为对照组和研究组。对照组患者给予0.15％更昔洛韦眼用凝胶1滴，每日4次；若为浅层型患者，在给予0.15％更昔洛韦眼用凝胶2～5 d后，待角膜上皮修复至荧光素染色弱阳性时+阿昔洛韦片0.2 g，口服，每日3次+吲哚美辛片25 mg，口服，每日3次；深层型患者在浅层型患者治疗的基础上给予复方托吡卡胺滴眼液1滴，早晚各1次。研究组患者若为浅层型给予0.15％更昔洛韦眼用凝胶2～5 d后，待角膜上皮修复至荧光素染色弱阳性时+0.02％氟米龙滴眼液1滴，每日4次+阿昔洛韦片（用法用量同对照组）+吲哚美辛片（用法用量同对照组）；深层型患者在浅层型患者治疗的基础上给予复方托吡卡胺滴眼液（用法用量同对照组）。两组疗程均为7d。观察两组患者的临床疗效，平均治疗时间，复发率及不良反应发生情况。结果：研究组患者总有效率显著高于对照组，平均治疗时间显著短于对照组，复发率显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者浅层型总有效率比较，差异无统计学意义（P＞0.05）；研究组患者深层型总有效率显著高于对照组，差异有统计学意义（P＜0.05）。两组患者治疗期间均未见明显不良反应发生，肝肾功能、血尿常规均无异常。结论：氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的疗效显著，可显著缩短病程，降低复发率，安全性较好，尤其适用于深层型单疱病毒性角膜炎患者。“,”OBJECTIVE:To observe the efficacy and safety of fluorometholone combined with ganciclovir in the treatment of herpes simplex keratitis. METHODS:72 patients with herpes simplex keratitis were randomly divided into control group and study group. Control group was treated with 1 drop of 0.15% Ganciclovir ophthalmic gel,4 times every day;shallow-type patients were treated with 0.15% Ganciclovir ophthalmic gel for 2-5 d,then 0.2 g Fluorometholone tablet was orally given when corneal epitheli-al repaired to positive fluorescein staining,3 times a day + 25 mg Indomethacin tablet,orally,3 times a day;deep-type patients were additionally treated with 1 drop of Compound tropicamide eye drop,once every morning and night. Shallow-type patients in study group were treated with 0.15% Ganciclovir ophthalmic gel for 2-5 d,then 1 drop of 0.025% Flumetholon eye drop was giv-en when corneal epithelial repaired to positive fluorescein staining,4 times every day+Indomethacin tablet(the same dose with con-trol group)+Indomethacin tablet(the same dose with control group);deep-type patients were additionally treated Compound tropi-camide eye drop(the same dose with control group). The treatment course for both groups was 7 d. Clinical efficacy,average treat-ment time,recurrence rate and incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in study group was significantly higher than control group,average treatment time was significantly shorter than control group,recur-rence rate was significantly lower than control group,the differences were statistically significant(P0.05);the total effective rate for deep-type patients in study group was significantly higher than control group,the difference was statistically significant(P<0.05). There were no obvious adverse reactions during treatment,and liver and kidney function,blood and urine routine showed no abnormality. CON-CLUSIONS:Fluorometholone combined with ganciclovir has significant efficacy in the treatment of herpes simplex keratitis,it can significantly shorten treatment course and reduce recurrence rate,with good safety,especially for deep-type patients.