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目的 探讨雌激素受体 (ER)对乳腺癌患者预后的影响。方法 对 1993年 1月～ 1998年 8月间经手术治疗的 2 85例乳腺癌患者 ,用免疫组织化学法检测其乳腺标本的ER状况。结果 2 85例乳腺癌ER检测阳性率为 6 8 0 7% ,同期伴腋窝淋巴结转移的乳腺癌 188例的ER阳性率为 6 6 49% ,二者无显著差异 (P <0 0 5 )。术后发生复发转移 11例 ,ER阴性组发生复发转移多于阳性组 ,且易转移至内脏 ,ER阳性和阴性组的复发转移率分别为 1 5 5 %和 8 79%。结论 乳腺癌的ER状况是影响预后的重要因素 ,当ER阴性时 ,应积极施行化学药物治疗以提高疗效
Objective To investigate the effect of estrogen receptor (ER) on the prognosis of patients with breast cancer. Methods From February 1993 to August 1998, a total of 2 85 breast cancer patients undergoing surgical treatment were enrolled in this study. The ER status of the breast specimens was examined by immunohistochemistry. Results The positive rate of ER in 2 85 cases of breast cancer was 68.07%. The positive rate of ER in 188 cases of breast cancer with axillary lymph node metastasis in the same period was 6 6 49%. There was no significant difference (P <0.05). Recurrence and metastasis occurred in 11 cases. The recurrence and metastasis in ER-negative group was more than that in positive group, and it was easy to metastasize to internal organs. The recurrence and metastasis rates in ER-positive and -negative groups were 15.5% and 879%, respectively. Conclusion The ER status of breast cancer is an important factor affecting the prognosis. When ER is negative, chemotherapy should be actively carried out to improve the therapeutic effect