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已知原发性微小病变型肾病(MCN)和局灶节段性肾小球硬化(FSGS)。与T 淋巴细胞功能不全有关。传统的治疗药物有皮质类固醇和/或免疫抑制剂,如苯丁酸氮芥、硫唑嘌呤和环磷酰胺。但成人患者多易复发,完全缓解率MCN 约60%,FSGS20%,作者晚近以哌氟喹酸(Pefloxacin)治疗2例肾病综合征获得良效。现摘译1例如下:患者因MCN 肾病综合征第8次复发同意接受哌氟喹酸治疗。以往曾用皮质类固醇,环磷酰胺及硫唑嘌呤,但终未缓解。哌氟喹酸治疗的8天内24小时尿蛋白定量从15克降至0.15克、2周后停药,3月后
Primary minimal nephropathy (MCN) and focal segmental glomerulosclerosis (FSGS) are known. T lymphocyte dysfunction and related. Traditional therapies are corticosteroids and / or immunosuppressive agents such as chlorambucil, azathioprine and cyclophosphamide. However, patients with more prone to relapse in adults, complete remission rate of MCN about 60%, FSGS20%, the authors recently treated with flufenamic acid (Pefloxacin) treatment of 2 cases of nephrotic syndrome obtained good effect. A case of translation is now as follows: patients with MCN nephrotic syndrome, the first eight relapse agreed to accept the treatment of pioprofolate. In the past have used corticosteroids, cyclophosphamide and azathioprine, but did not ease. The fluoxetine 24-hour urine protein quantification dropped from 15 grams to 0.15 grams within 8 days after treatment with piperpullutic acid and discontinued after 2 weeks. After 3 months