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目的评价乳腺癌患者化疗前后胰岛素样生长因子Ⅰ(IGF-Ⅰ)水平变化的临床意义。方法采用免疫放射法检测20例乳腺癌化疗前后IGF-Ⅰ水平,随访观察患者有无出现复发或转移并作对比分析。结果乳腺癌患者化疗后血清IGF-Ⅰ水平明显低于化疗前(P<0.05),同时20例患者随访1年均未出现复发或转移。结论血清IGF-Ⅰ水平检测可作为乳腺癌疗效和判断预后的一个监测指标。
Objective To evaluate the clinical significance of the changes of insulin-like growth factor Ⅰ (IGF-Ⅰ) in patients with breast cancer before and after chemotherapy. Methods The levels of IGF-Ⅰ in 20 cases of breast cancer before and after chemotherapy were detected by immuno-radioimmunoassay. The recurrence or metastasis of the patients were observed and compared. Results The level of serum IGF-Ⅰ in patients with breast cancer after chemotherapy was significantly lower than that before chemotherapy (P <0.05). At the same time, no recurrence or metastasis was found in 20 patients after one year of follow-up. Conclusion Serum IGF-Ⅰ level can be used as a monitoring indicator of the efficacy and prognosis of breast cancer.