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目的探讨孕妇早期检测血清甲状腺激素的临床意义。方法选取我院2011年10月-2013年10月早期妊娠孕妇536例,采用罗氏电化学发光免疫分析仪检测血清甲状腺素(T4)、三碘甲腺原氨酸(T3)、促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)和游离甲状腺素(FT4)水平,并与同期520例非妊娠健康妇女的血清甲状腺激素水平进行比较,分析早期检测的临床意义。结果观察组T4和T3水平显著高于对照组,TSH水平显著低于对照组,差异均有统计学意义(P<0.05),FT3水平低于对照组,FT4水平高于对照组,但差异无统计学意义(P>0.05);甲状腺功能异常者72例(13.4%),以甲减和亚临床甲减者居多。结论早期妊娠孕妇T4和T3水平升高,TSH水平降低,早期检测血清甲状腺激素,有助于及时发现甲状腺功能异常者和采取干预措施。
Objective To investigate the clinical significance of detecting serum thyroid hormones in pregnant women early. Methods 536 pregnant women of early pregnancy in our hospital from October 2011 to October 2013 were selected for detection of serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone TSH, free triiodothyronine (FT3) and free thyroxine (FT4) were measured and compared with the serum levels of thyroid hormone in 520 non-pregnant women during the same period. The clinical significance of early detection was analyzed. Results The levels of T4 and T3 in the observation group were significantly higher than those in the control group, and the levels of TSH in the observation group were significantly lower than those in the control group (P <0.05). The levels of FT3 in the observation group were lower than those in the control group, but the levels of FT4 in the observation group were higher than those in the control group Statistical significance (P> 0.05); Thyroid dysfunction in 72 patients (13.4%), with hypothyroidism and subclinical hypothyroidism were the majority. Conclusion The levels of T4 and T3 in early pregnant women are elevated and the level of TSH is decreased. Early detection of serum thyroid hormones helps to detect thyroid dysfunction in time and to take interventions.