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本文采用戊四氮（ＰＴＺ）诱发大鼠癫痫模型，动态观察了脑组织中额叶、海马、丘脑、下丘脑、中脑及纹状体中亮－脑啡肽（Ｌ－Ｅｎｋ）含量的变化。结果发现，应用ＰＴＺ后，癫痫大发作大鼠及未出现大发作的大鼠额叶、丘脑、中脑及纹状体中Ｌ－Ｅｎｋ含量均明显升高，两组间无明显差异；但大发作大鼠下丘脑的Ｌ－Ｅｎｋ含量显著高于对照组及无大发作组。大发作后６小时内，额叶、中脑、丘脑及下丘脑的Ｌ－Ｅｎｋ恢复至正常，而纹状体中Ｌ－Ｅｎｋ于２４小时内恢复至正常；海马的Ｌ－Ｅｎｋ含量各组间无明显变化。提示Ｌ－Ｅｎｋ可能参与了癫痫的发生过程
In this paper, pentylenetetrazole (PTZ) -induced epilepsy model was induced in rats, and the changes of L-Enk in the frontal lobe, hippocampus, thalamus, hypothalamus, midbrain and striatum were dynamically observed . The results showed that the content of L-Enk in frontal lobe, thalamus, midbrain and striatum of rats with epileptic seizures and without major attack were significantly increased after PTZ application, with no significant difference between the two groups The content of L-Enk in the hypothalamus of the attacking rats was significantly higher than that of the control group and the absence of major attack group. L-Enk in the frontal lobe, midbrain, thalamus and hypothalamus returned to normal within 6 hours after the onset of attack, whereas L-Enk in the striatum returned to normal within 24 hours. L-Enk content in the hippocampus No significant changes. Suggesting that L-Enk may be involved in the process of epilepsy