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本研究观察了α-黑色素细胞刺激素（α-MSH）对家兔白细胞介素-1β（IL-1β）发热效应及下丘脑组织腺苷环-磷酸（cAMP）含量的影响；同时观察了下丘脑组织体外培养过程中，α-MSH对IL-1β刺激下丘脑释放cAMP的影响。结果显示：α-MSH能显著降低IL-1β引起的体温升高（P＜0．05）；同时抑制下丘脑组织cAMP含量的增高（P＜0．01）。IL-1β与下丘脑组织培养，其上清液中cAMP含量明显升高（P＜0．01）；而预先加入α-MSH，再加同量IL-1β培养，则培养上清液的cAMP含量接近对照组。体内外实验表明，α-MSH抑制中枢发热介质cAMP，的生成可能是其解热的重要机制之一.
In this study, we observed the effect of α-MSH on the fever and the content of adenosine ring-and-cAMP in hypothalamus of rabbits. Effect of α-MSH on cAMP released from hypothalamus stimulated by IL-1β in cultured thalamus tissue. The results showed that α-MSH could significantly decrease the body temperature induced by IL-1β (P <0.05) and inhibit the increase of cAMP in hypothalamus (P <0.01). IL-1β and hypothalamus tissue culture, the supernatant cAMP content was significantly increased (P <0.01); pre-addition of α-MSH, plus the same amount of IL-1β culture, the culture supernatant cAMP Content close to the control group. In vitro and in vivo experiments show that α-MSH inhibition of the central heating medium cAMP, the generation may be one of its important mechanisms of antipyretic.