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目的 研究胃癌中CD44的表达 ,旨在探讨CD44在胃癌发生发展中的作用及临床意义。方法 采用免疫组化S-P方法检测CD44S及CD44变异体V6在 5 4例胃良性病变 (BGD)及 6 3例胃癌 (GC)中的表达 ,并比较了阳性表达与肿瘤组织分型、淋巴转移等的关系。结果 CD44S在浅表性胃炎 (CSG)、萎缩性胃炎伴肠上皮化生 (CAG/IM)及GC中表达阳性率分别为 46 5 %、5 7 1%、5 2 4%。CD44V6在CSG中无表达 ,在CAG/IM及GC中表达阳性率为 :19 1%和5 3 7%。在有淋巴转移组CD44V6表达率 6 8 6 % ,明显高于无转移组 3 5 7%。在肠型胃癌中 ,CD44V6表达率 73 7% ,明显高于弥漫型胃癌 2 4%。CD44S阳性表达与有否淋巴转移及组织分型无关。结论 CD44S、CD44V6在胃癌中均有表达 ,CD44V6表达率与胃癌淋巴转移及组织来源有关。
Objective To study the expression of CD44 in gastric cancer in order to investigate the role and clinical significance of CD44 in the development of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of CD44S and CD44 variant V6 in 54 cases of benign gastric lesions (BGD) and 63 cases of gastric carcinoma (GC). The positive expression and tumor histological type, lymph node metastasis were compared. Relationship. Results The positive rates of CD44S in superficial gastritis (CSG), atrophic gastritis with intestinal metaplasia (CAG/IM) and GC were 46.5%, 57.1% and 52.4%, respectively. There was no expression of CD44V6 in CSG, and the positive expression rates in CAG/IM and GC were: 19 1% and 53 7%. In the group with lymphatic metastasis, the expression rate of CD44V6 was 646 percent, which was significantly higher than that of the non-metastasis group 3.57%. In intestinal type gastric cancer, the expression rate of CD44V6 was 73.7%, which was significantly higher than that of diffuse type gastric cancer 24%. The positive expression of CD44S was not associated with lymph node metastasis and histological type. Conclusion CD44S and CD44V6 are all expressed in gastric cancer. The expression of CD44V6 is related to lymph node metastasis and tissue origin.