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目的:研究并分析生丹参总酚酸联合生脉注射液在体外循环中的心肌保护作用。方法:采用随机数字表法将90例需要体外循环手术的患者分为对照组和研究组组,其中研究组应用含有丹参总酚酸联合生脉注射液的心脏停搏液,对照组应用常规治疗,两组患者分别于术前30min,术后30 min、24 h抽取静脉血,测定心肌肌酸激酶同功酶(CK-MB)心肌钙蛋白(c Tn I),通过这两项血浆标记物的数值比较有无差异。结果:研究组应用含有丹参总酚酸联合生脉注射液的心脏停搏液,与对照组常规治疗相比,其血浆心肌肌酸激酶同功酶CK-MB含量在术后30 min、术后24 h有显著差异,P<0.05,;其血浆心肌钙蛋白c Tn I含量含量在术后30 min、术后24 h与对照组相比亦有显著差异,P<0.05,差异具有统计学意义。结论:在心停搏液中加入丹参总酚酸联合生脉注射液在体外循环手术中具有确切的临床疗效,生脉注射液能够减少患者的心肌缺血再灌注损伤,减少患者心肌损害,对心肌具有保护作用,值得临床上进一步研究和推广应用。
Objective: To study and analyze the cardioprotective effects of Salvia miltiorrhiza combined with Shengmai injection on cardiopulmonary bypass. Methods: Ninety cases of patients undergoing cardiopulmonary bypass were divided into control group and study group by random number table. The study group received cardioplegic solution containing salvianolic acid combined with Shengmai injection and the control group received routine treatment , Venous blood was drawn at 30 min before operation, 30 min and 24 h after operation, respectively. The levels of cardiac troponin kinase (CK-MB) cardiac troponin (cTn I) were measured. The two plasma markers Whether the difference between the numerical comparison. Results: In the study group, cardioplegic solution containing Salvia Total Salviae Miltiorrhiza combined with Shengmai Injection was used. Compared with the control group, CK-MB content of plasma creatine kinase at 30 min after operation, 24 h were significantly different, P <0.05, the content of plasma cardiac troponin TnI in the postoperative 30 min, 24 h after surgery compared with the control group also had significant differences, P <0.05, the difference was statistically significant . Conclusion: The addition of salvia miltiorrhiza combined with Shengmai injection in cardiac cardioplegia has the exact clinical curative effect in cardiopulmonary bypass. Shengmai injection can reduce the myocardial ischemia-reperfusion injury, reduce the myocardial damage, Has a protective effect, it is worth further study and promote clinical application.