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大肠杆菌（Escherichiacoli）是人体肠道正常菌群之一，也是临床上细菌感染的常见病原菌[1]。早在1940年就有大肠杆菌产卜内酸胶酶的报道，而β-内酰胺抗生素在临床广泛应用已近半个世纪。现就大肠杆菌产β-内酰胺酶（产酶）及有关研究进展综述如下。1大肠杆菌对β-内酰胺抗生?
Escherichia coli is one of the normal human intestinal flora and is also a common pathogen of bacterial infection in clinic [1]. As early as 1940 there are reports of E. coli production of Bacillus acidase enzyme, and β-lactam antibiotics widely used in clinical nearly half a century. Escherichia coli production of β-lactamase (enzyme production) and related research are summarized below. 1 Escherichia coli β-lactam antibiotic?