环孢菌素 A(CSA)是一种有效的抑制活性 T细胞增殖,阻止其生成白细胞介素2(IL-2)的免疫抑制剂。已有报道用 CSA 治疗银屑病有效。银屑病的特征是表皮过度增殖。许多治疗银屑病有效药物的作用机理均是抗增殖。为了证实 CSA 对角朊细胞的增殖有无影响,本文作者研究了 CSA 对正常和异常角朊细胞的作用。取 C3H 鼠耳和躯干部皮肤的正常表皮细胞,以及各种鼠和人的异常细胞株(鼠异常角朊细胞 Pam 212,人鳞状细胞癌A431),以 RPMI 1640作为细胞培养基,于含有 Cyclosporine A (CSA) is an effective immunosuppressant that inhibits the proliferation of active T cells and prevents them from producing interleukin 2 (IL-2). It has been reported that treatment of psoriasis with CSA is effective. Psoriasis is characterized by hyperproliferation of the epidermis. Many of the mechanisms of action for psoriasis-effective drugs are antiproliferative. To confirm whether CSA had any effect on the proliferation of keratinocytes, the authors studied the effects of CSA on normal and abnormal keratinocytes. Normal epidermal cells of C3H murine and trunk skin, as well as various murine and human abnormal cell lines (murine dyskaloid Pam 212, human squamous cell carcinoma A431), RPMI 1640 as cell culture medium,