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草分枝杆菌为一种多功能免疫刺激剂,主要通过影响免疫应答反应而调节机体免疫功能,除治疗肺结核等疾病,也应用于恶性肿瘤的治疗和预防。目前国外临床已广泛应用于膀胱癌的治疗,取得了较好的疗效。草分枝杆菌对恶性肿瘤细胞生长抑制作用的机制,目前认为:①刺激癌细胞浸润的单核-巨噬细胞合成白细胞介素12(已知具有抗癌活性的细胞因子);②抗血管新生,抑制肿瘤血管生成;③调节细胞增殖周期、诱导癌细胞凋亡,抑制癌细胞的增殖和存活。
Mycobacterium phlei is a multi-functional immunostimulant which regulates immune function mainly through affecting the immune response. It is also used in the treatment and prevention of malignant tumors in addition to the treatment of tuberculosis and other diseases. At present, foreign clinical has been widely used in the treatment of bladder cancer, and achieved good results. Mycobacterium tuberculosis on malignant tumor cell growth inhibitory mechanism, the current view: ① stimulate the infiltration of cancer cells monocyte - macrophage synthesis of interleukin 12 (known to have anti-cancer activity of cytokines); ② anti-angiogenesis , Inhibition of tumor angiogenesis; ③ regulation of cell proliferation cycle, induced apoptosis of cancer cells, inhibition of cancer cell proliferation and survival.