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目的探讨心力衰竭(HF)患儿血清基质金属蛋白酶-2(MMP-2)水平变化及临床意义。方法2005年3月至2007年3月于山东省济南市第四人民医院儿科住院的慢性心力衰竭(CHF)患儿51例(HF组),同时选该院门诊体检健康儿童30名作正常对照。测定HF组和对照组的血清MMP-2和N末端脑钠肽(NT-proBNP)水平、左心功能参数,同时分析HF组血清MMP-2与NT-proBNP、左心功能参数之间的相关性。结果HF组血清MMP-2水平显著高于对照组,且随着HF程度的加重而显著升高(P<0.01);MMP-2与NT-proBNP之间具有良好的相关性(r=0.78,P<0.01)。结论血清MMP-2水平的检测有助于动态评估HF患儿病情的严重程度及预后。
Objective To investigate the changes of serum matrix metalloproteinase-2 (MMP-2) in children with heart failure (HF) and its clinical significance. Methods From March 2005 to March 2007, 51 children with chronic heart failure (CHF) hospitalized in pediatrics of the Fourth People ’s Hospital of Ji’nan, Shandong Province were enrolled. Thirty healthy children in the hospital were selected as normal controls. Serum levels of MMP-2, NT-proBNP and left ventricular function parameters in HF group and control group were determined. The correlation between serum MMP-2, NT-proBNP and left ventricular function parameters in HF group was also analyzed Sex. Results The level of serum MMP-2 in HF group was significantly higher than that in control group (P <0.01), and there was a good correlation between MMP-2 and NT-proBNP (r = 0.78, P <0.01). Conclusion The detection of serum MMP-2 level is helpful to evaluate the severity and prognosis of HF patients dynamically.