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目的 :探讨胃肠道间质瘤 (gastrointestinalstromaltumors ,GIST)的临床表现、组织学和免疫组化的特点及治疗方法。方法 :对 1994年 3月～ 2 0 0 3年 12月收治的 5 0例GIST患者的临床和组织学资料进行回顾性分析 ,并应用 4种抗体 (C -kit ,CD3 4,SMA ,S -10 0 )通过免疫组化方法进行分析研究。结果 :本GIST主要发生在胃 ( 60 %3 0 /5 0 )和小肠 ( 2 6%13 /5 0 ) ,结直肠较少 ( 14 %7/5 0 )良性 14例。潜在恶性 6例 ,恶性 3 0例 ,C -kit阳性表达率 ( 92 %4 6/5 0 ) ,CD3 4阳性表达率 ( 88%4 4/5 0 )肿瘤切除率 10 0 %。结论 :GIST是胃肠道最常见的间质性肿瘤 ,C -kit(CD117)和CD3 4标记阳性是确诊GIST最有价值的诊断依据 ,手术是主要治疗手段 ,术中的正确判断 ,指导术式选择也至关重要
Objective: To investigate the clinical manifestations, histological features and immunohistochemical characteristics of gastrointestinal stromal tumors (GISTs) and the treatment methods. Methods: The clinical and histological data of 50 GIST patients admitted from March 1994 to December 2003 were retrospectively analyzed. Four antibodies (C - kit, CD34, SMA, S - 10 0) by immunohistochemistry analysis. Results: The GIST mainly occurred in the stomach (60%) and the small intestine (26%, 13/50), and the colorectum was less (14%, 7/50) in 14 cases. 6 cases were potentially malignant, 30 cases were malignant, the positive rate of C-kit was 92% 4 6/5 0, and the rate of CD3 4 was 88% 4 4/5 0. Conclusion: GIST is the most common interstitial tumor of the gastrointestinal tract. The positive results of C-kit (CD117) and CD34 markers are the most valuable diagnostic criteria for the diagnosis of GIST. Surgery is the main treatment method, and the correct judgment and guidance Type selection is also crucial