论文部分内容阅读
Nerve growth factor(NGF)is a neurotrophic factor critical for cholinergic neuronal survival,phenotypic maintenance and plasticity in the mammalian brain.NGF has been implicated in the pathogenesis of neurodegenerative disorders,with direct administration of NGF into the brain capable of facilitating neuroprotection and repair.To date,NGF has been proposed as a potential therapy for Alzheimer's disease(AD)and Parkinson's disease due to its regenerative effects on cholinergic neurons located in the basal forebrain and striatum,respectively.In other neurodegenerative diseases,including progressive supranuclear palsy,amyotrophic lateral sclerosis(ALS),vascular dementia,Lewy body dementia and frontotemporal lobar dementia,emerging evidence has revealed the impact of cholinergic dysfunction on clinical outcomes,thereby supporting the therapeutic potential of NGF.In this perspective,we will review the current challenges of NGF-related therapy for clinical use and address the relevance of magnetic resonance imaging(MRI)-guided focused ultrasound(MRIgFUS)-induced blood-brain barrier(BBB)permeability enhancement for the delivery of NGF-related compounds and brain repair.