,Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identific

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Dear Editor,Bipolar disorder (BD) is a debilitating psychiatric mood disorder affecting approximately 1%-3% of the population worldwide (Merikangas, 2007).Bipolar disorder is characterized by recurrent episodes of depression, hypomania, mania,or mixed states, and it has a poor outcome, with high rates of relapse, lingering residual symptoms, cognitive impairment,and functional impairment (Moreno et al., 2007) Although various etiopathological hypotheses conceming the disease have been reported, the pathophysiology underlying BD remains poorly understood (Gawryluk and Young, 2011).
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