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目的:探讨在限制代谢因素后丙型肝炎病毒(HCV)感染对胰岛素敏感性和血清脂联素水平的影响。方法:以2009年1月～2010年12月我院收治的非糖尿病慢性HCV感染者35例为研究组,健康受试者35例为对照,两组空腹血糖水平、体重指数(BMI<26 kg/m~2)和腹部超声检查均正常。比较两组的胰岛素抵抗指数和血清脂联素水平。结果:研究组的胰岛素抵抗指数和血清脂联素水平无显著性差异(P>0.05)。结论:在无代谢紊乱如肥胖、糖尿病和脂肪肝时,单独慢性HCV感染不影响胰岛素敏感性和血清脂联素水平。
Objective: To investigate the effect of hepatitis C virus (HCV) infection on insulin sensitivity and serum adiponectin levels after limiting metabolic factors. Methods: From January 2009 to December 2010, 35 patients with non-diabetic chronic HCV infection admitted to our hospital were selected as research group and 35 healthy subjects as control group. Fasting blood glucose, body mass index (BMI <26 kg / m ~ 2) and abdominal ultrasound were normal. Insulin resistance index and serum adiponectin levels were compared between the two groups. Results: There was no significant difference in insulin resistance index and serum adiponectin between the two groups (P> 0.05). CONCLUSION: Chronic HCV infection alone does not affect insulin sensitivity and serum adiponectin levels in the absence of metabolic disorders such as obesity, diabetes and fatty liver.