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血吸虫在终宿主的组织中并不增殖。实验室研究及流行病学研究均表明感染后成虫负荷数的明显减少(约60％)能显著地减轻病理损害及疾病的传播。血吸虫感染的这两个特性是研制血吸虫疫苗策略的基点。血吸虫病的病理损害主要是由活虫卵的沉积所引起,因此疫苗诱导的免疫力主要在于使成虫产卵减少,而不在于是否伴有虫负荷的减少。 近五年来因血吸虫疫苗候选抗原的验证及其分子克隆方面的广泛研究,已有数种编码曼氏血吸虫抗原蛋白的基因克隆,其中
Schistosomes do not proliferate in the tissues of the final host. Laboratory studies and epidemiological studies have shown that a significant reduction in the number of adult worms after infection (about 60%) can significantly reduce the pathological damage and the spread of the disease. These two characteristics of schistosomiasis infection is the basis for the development of schistosome vaccine strategy. The pathological damage of schistosomiasis is mainly caused by the deposition of live eggs, so the immune-induced immunity of the vaccine is mainly to reduce the spawning of adults, not whether it is accompanied by the reduction of insect burden. Several gene clones encoding the Schistosoma mansoni antigen protein have been available for validation of candidate antigens for schistosoma vaccine and molecular cloning in the past five years