逼尿肌-括约肌协同失调是指逼尿肌收缩时外尿道括约肌的不随意收缩。它可引起排尿障碍,并可导致泌尿系统疾病,如输尿管返流性肾病和肾功衰竭。多见于脊髓损伤病人,以往采用的解痉药物治疗和插导尿管等方法效果不理想。局部注射肉毒素A(BTA)是目前较新的一种治疗方法。经膀胱镜注射BTA减少外尿道括约肌不随意收缩已有报道。本文报道5例四肢瘫痪病人经会阴注射BTA治疗逼尿 Detrusor - Sphincter synergy refers to involuntary contraction of the external urethral sphincter when detrusor contractions. It can cause voiding disorders and can lead to urological disorders such as ureteral reflux nephropathy and renal failure. More common in patients with spinal cord injury, antispasmodic drug therapy used in the past and catheterization methods such as the effect is not satisfactory. Local injection of botulinum toxin A (BTA) is a relatively new treatment. Transurethral injection of BTA to reduce external urinary sphincter contraction has not been reported. This article reports 5 cases of quadriplegia patients via the perineal injection of BTA treatment of detrusor