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目的:观察内皮素在肺血栓栓塞溶栓过程中的变化规律,探讨内皮素在肺动脉压力变化中的意义。方法:肺动脉内注入栓子建立肺栓塞动物模型,测量栓塞前后及溶栓前后肺动脉平均压力(PAMP)、右心室收缩压(RVSP),用放免法测定血浆内皮素(ET)。结果:动物模型在栓塞后PAMP及RVSP立即升高,溶栓后明显下降,至溶栓后4hPAMP及RVSP仍然高于注入栓子之前。ET值也呈现相同的变化规律,而且ET与PAMP显著相关。结论:肺栓塞溶栓过程中ET及PAMP均呈现出规律性变化,而且二者密切相关,ET可能参与了急性肺栓塞后肺动脉压力上升。
Objective: To observe the changes of endothelin in pulmonary thromboembolism thrombolysis, and to explore the significance of endothelin in the changes of pulmonary artery pressure. Methods: Pulmonary embolism was injected into the pulmonary artery to establish pulmonary embolism model. The mean pulmonary artery pressure (PAMP) and right ventricular systolic pressure (RVSP) were measured before and after embolization and before and after thrombolysis. Plasma endothelin (ET) was measured by radioimmunoassay. Results: After the embolization, the PAMP and RVSP increased immediately after thrombolysis, but decreased significantly after thrombolysis. The levels of PAMP and RVSP were still higher 4 h after thrombolysis than before embolization. ET also showed the same change rule, and ET and PAMP significant correlation. CONCLUSION: Both ET and PAMP show regular changes during thrombolysis of pulmonary embolism, and the two are closely related. ET may be involved in pulmonary hypertension after acute pulmonary embolism.