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目的探讨联合应用奥美拉唑、左氧氟沙星、阿莫西林三种药物对消化性溃疡的治疗效果。方法随机选择消化性溃疡患者60例,均为Hp阳性,并随机分为治疗组与对照组,各30例。给予治疗组患者奥美拉唑、左氧氟沙星、阿莫西林三种药物进行治疗,经1周治疗,改为口服20mg奥美拉唑治疗3周。给予对照组患者奥美拉唑、甲硝唑、阿莫西林三种药物进行治疗,经1周治疗,改为奥美拉唑口服,治疗3周。经过4周的治疗后,对比两组的治疗情况与根除Hp的情况。结果对比两组的治疗效果,两组的治愈率分别为50%与33.3%,有效率分别为90%与83.3%,有显著性差异,有统计学意义(P<0.05);两组Hp的根除率分别为93.3%与53.3%,有显著性差异,具有统计学意义(P<0.05)。结论治疗组所采用的三联疗法是治疗消化性溃疡,根除幽门螺杆菌的有效手段。
Objective To investigate the therapeutic effect of combination of omeprazole, levofloxacin and amoxicillin on peptic ulcer. Methods Sixty patients with peptic ulcer were randomly selected. All of them were Hp positive and were randomly divided into treatment group and control group, with 30 cases in each group. Patients in the treatment group were treated with omeprazole, levofloxacin and amoxicillin. After one week of treatment, they were treated with omeprazole 20 mg orally for 3 weeks. Patients in the control group were treated with omeprazole, metronidazole and amoxicillin. After one week of treatment, omeprazole was given orally for 3 weeks. After 4 weeks of treatment, the treatment and eradication of Hp were compared between the two groups. Results The curative effect of two groups were compared. The cure rates of the two groups were 50% and 33.3%, the effective rates were 90% and 83.3%, respectively, with significant difference (P <0.05) The eradication rates were 93.3% and 53.3%, respectively, with significant difference (P <0.05). Conclusion The triple therapy used in the treatment group is an effective method for the treatment of peptic ulcer and Helicobacter pylori eradication.