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目的探讨精神科药物联用与血清肝酶升高之间存在的相关性,寻找控制血清肝酶升高的对策。方法选取2013年11月至2014年11月大连市第七人民医院接受药物联用的33例精神科患者,于治疗前、治疗后1个月、治疗后2个月分别予以测量其肝酶类指标,统计血清肝酶异常升高的病例。结果血清肝酶升高病例中,联合使用利培酮以及氯氮平的患者最多,其次是联合使用碳酸锂以及喹硫平等。治疗1个月后,机体血清肝酶升高最为突出,而治疗2个月后,血清肝酶已从单项异常逐渐变成多项异常,并且呈现出不断升高的态势,较治疗前、治疗后患者的谷氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶以及谷氨酰转肽酶等指标均已发生明显变化,差异均有统计学意义(均P<0.05)。结论临床上,精神科药物联用与血清肝酶升高之间存在一定的相关性。
Objective To explore the correlation between the combination of psychotropic drugs and serum hepatic enzymes in order to find a way to control the increase of serum hepatic enzymes. Methods From November 2013 to November 2014, 33 cases of psychiatric patients in Dalian Seventh People’s Hospital who received combination of drugs were measured before treatment, one month after treatment and two months after treatment, and their liver enzymes Indicators, statistical abnormal increase in serum liver enzymes cases. Results Serum liver enzymes increased in patients with combined use of risperidone and clozapine most patients, followed by the combined use of lithium carbonate and quetiapine equal. After 1 month of treatment, the most prominent increase of serum liver enzymes was in the body. After 2 months of treatment, the serum liver enzymes gradually became abnormal from single abnormality and showed an increasing trend, which was higher than that before treatment and treatment After patients with glutamate aminotransferase, aspartate aminotransferase, alkaline phosphatase and glutamyl transpeptidase and other indicators have changed significantly, the differences were statistically significant (P <0.05). Conclusion In clinical practice, there is a certain correlation between psychotropic drugs and serum liver enzymes.