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为了明确感染Delsa因子(6)与某种急性乙型肝炎迁延不愈的关系,作者检测了1978～1981年在意大利三个医疗中心:意大利南部、意大利岛、意大利中部诊断为急性乙型肝炎慢性化的58例б标记。用放射免疫分析法(RIA)测定IgG抗б(占抗б的绝大多数)和IgM抗б,用固相放射免疫法(SPRIA)测定血清б抗原,同时测HBeAg和抗HBe,IgG抗HBc和IgM抗HBc、HBsAg。结果发现:58例血清б抗原全部阴性;急性发作期34例IgM抗б和(或)IgG抗б滴度增高;IgG抗б都在1～3个月内增高到高滴度水平(10~3～10~5),且持续不降。此58例的б感染率,意大利南部为22/27(81%),意大利岛为12/18(67%),意大利中部为0/13;总б感染率为34/58(58%)。
In order to clarify the relationship between Delsa factor (6) and the delayed healing of some acute hepatitis B, the authors examined three medical centers in Italy from 1978 to 1981: southern Italy, the Italian island, central Italy diagnosed as chronic hepatitis B 58 cases of б mark. Immunoassay (RIA) was used to determine IgG anti-б (the majority of anti-б) and IgM anti-б, using serum radioimmunoassay (SPRIA) serum б antigen, simultaneous detection of HBeAg and anti-HBe, And IgM anti-HBc, HBsAg. The results showed that all the 58 cases were negative for the serum anti-б antigen; 34 cases of anti-б and / or IgG anti-б titers were increased in the acute attack; IgG anti б increased to high titers within 10 ~ 3 ~ 10 ~ 5), and continued to decline. The prevalence of infection in these 58 cases was 22/27 (81%) in southern Italy, 12/18 (67%) in Italy and 0/13 in central Italy; the overall infection rate was 34/58 (58%).