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目的探讨氟喹诺酮类药物的不良反应。方法收集30例上报的氟喹诺酮类药物不良反应的病人,回顾性分析所有研究对象使用药物具体名称、给药方式、原患疾病及不良反应的临床表现。结果使用左氧氟沙星出现不良反应的病例数最高,占构成比的73.33%,其次是洛美沙星占16.67%,诺氟沙星占10%;使用静脉滴注出现不良反应占构成比的80%,口服用药仅占到20%;原患疾病系统中最多的是呼吸系统疾病,占构成比的40%,其次为泌尿系统,占33.33%,消化系统占16.67%,循环系统占10%;不良反应表现最多的系统是皮肤,占构成比的43.33%,其次为消化系统,占20%,神经系统表现占16.67%,心血管系统表现占10%,其它占10%。结论临床加强氟喹诺酮类药物的使用管理,及时发现不良反应,及时处理。
Objective To investigate the adverse reactions of fluoroquinolones. Methods Thirty patients reported adverse reactions of fluoroquinolones were retrospectively analyzed, and the clinical manifestations of the patients were analyzed retrospectively. Results The patients with levofloxacin had the highest number of adverse reactions, accounting for 73.33% of the constituent ratio, followed by Lomefloxacin with 16.67% and Norfloxacin with 10%. Adverse reactions with intravenous infusion accounted for 80% Accounting for only 20% of the original drug system; the original disease system is the most respiratory diseases, accounting for 40% of the constitutional ratio, followed by the urinary system, accounting for 33.33%, accounting for 16.67% of the digestive system, circulatory system accounts for 10%; adverse reactions The largest number of systems is skin, accounting for 43.33% of the constituent ratio, followed by the digestive system, accounting for 20%, neurological system performance accounting for 16.67%, cardiovascular system performance accounting for 10% and others accounting for 10%. Conclusions The clinical management of fluoroquinolones should be strengthened, timely detection of adverse reactions and prompt treatment should be carried out.