采用BF3?Et2O催化和45kHz超声辐射下亚磷酸丁酯与邻氟苯甲醛、对三氟甲基苯胺在78～80℃,无溶剂条件下进行类Mannich反应,0.5h即可以较高收率获得目标化合物α-氨基膦酸酯(4),其结构经元素分析,1HNMR,IR及MS确认.对化合物晶体结构进行X衍射分析,结果表明化合物属单斜晶系,空间群P2(1)/c,晶胞参数a=1.348(4)nm,b=1.734(4)nm,c=1.099(3)nm,α=90°,β=109.71(4)°,γ=90°,V=2.417(11)nm3,Z=4,Dc=1.268μg/m3,μ=0.166mm-1,F(000)=968. Using BF3-Et2O as catalyst and butyl phosphite and o-fluorobenzaldehyde under 45 kHz ultrasonic irradiation, the Mannich reaction of trifluoromethylaniline was carried out at 78-80 ℃ with no solvent, The target compound α-amino phosphonate (4) was confirmed by elemental analysis, 1HNMR, IR and MS. The X-ray diffraction of the crystal structure of the compound showed that the compound belongs to the monoclinic space group P2 (1) / c = 1.099 (3) nm, α = 90 °, β = 109.71 (4) °, γ = 90 °, V = 2.417 (11) nm3, Z = 4, Dc = 1.268 μg / m3, μ = 0.166 mm-1, F (000) = 968.