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本研究目的是了解长期服用小剂量米非司酮对子宫肌瘤患者的子宫内膜的影响。２０名有症状的子宫肌瘤患者连续服用三个月米非司酮（１０ｍｇ／ｄ）后行子宫全切术，取子宫内膜做常规病理检查。治疗前和治疗期间每月定时测量子宫和肌瘤体积，同时测定内分泌激素。结果显示：肌瘤的体积平均缩小了４１．４％（Ｐ＜０．０１）；所有治疗组病人的子宫内膜形态异常，内膜腺体的大小和形态不规则，间质差异较大，未见不典型增生。血ＬＨ升高，ＦＳＨ降低，Ｅ２、Ｐ为卵泡早期到中期水平。结论为整个子宫内膜的变化与长期处于由米非司酮所引起非拮抗性雌激素环境相一致，同时也可以看到米非司酮对子宫内膜具有弱的孕激素影响。
The purpose of this study was to understand the effects of long-term use of low-dose mifepristone on endometrial cancer in patients with uterine fibroids. Twenty patients with symptomatic uterine fibroids were treated with mifepristone (10 mg / d) for three months and then underwent hysterectomy. The endometrium was taken for routine pathological examination. Uterine and fibroid volumes were measured regularly and monthly, before and during treatment, and endocrine hormones were measured at the same time. The results showed that the volume of fibroids was reduced by 41.4% on average (P <0.01). The morphology of endometrium was abnormal in all treatment groups, the size and shape of endometrial glands were irregular, No typical hyperplasia. Blood LH increased, FSH decreased, E2, P follicular early to mid-level. The conclusion is that the changes in the entire endometrium are consistent with long-term non-antagonistic estrogen conditions induced by mifepristone, and that mifepristone has a weak progestin effect on the endometrium.