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目的 探讨肺癌组织中 p5 3和Bcl 2蛋白的表达其与临床病理因素之间的关系。 方法 应用免疫组化S P法对 5 0例肺癌组织进行染色。结果 p5 3蛋白在肺癌中的表达率为 5 2 % ,与肺癌组织分化程度有关。Bcl 2蛋白表达率为 5 0 %。p5 3及Bcl 2表达率与淋巴结转移有关。 结论 肺癌组织中 p5 3、Bcl 2蛋白的检测可作为判断该肿瘤生物学行为及预后的指标
Objective To investigate the expression of p53 and Bcl2 protein in lung cancer and its relationship with clinicopathological factors. Methods Fifty cases of lung cancer tissues were stained with immunohistochemical SP method. Results The expression of p5 3 in lung cancer was 52%, which was related to the degree of differentiation of lung cancer. Bcl 2 protein expression rate of 50%. The expression of p5 3 and Bcl 2 is related to lymph node metastasis. Conclusion The detection of p53 and Bcl2 protein in lung cancer can be used as an index to judge the biological behavior and prognosis of the tumor