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目的分析并评价联合应用阿魏酸钠与弥可保治疗糖尿病周围神经病变的临床疗效及副作用。方法将我院自2011年2月至2012年2月期间收治60例糖尿病周围神经病变患者随机分成观察组30例与对照组30例。观察组将300mg的阿魏酸钠溶入250mL的生理盐水中,通过静脉滴注给药,再给予500μg的弥可保,通过肌肉注射给药,1次/d;对照组单独给予500μg的弥可保,通过肌肉注射给药,1次/d,两组治疗1个疗程均为2周时间。结果两组给药14d后,观察组15例显效,13例有效,2例无效;对照组7例显效,10例有效,13例无效,两组总有效率比较差异有统计学意义(uc=9.72,P<0.01),具有统计学意义;观察组共有2例发生局部血管刺激反应,对照组有1例发生轻度头晕,症状均较轻微,3例患者均未对继续治疗及观察产生影响。结论联合应用阿魏酸钠与弥可保能够有效改善糖尿病周围神经病变症状,该方法安全有效,值得在临床上广泛推广应用。
Objective To analyze and evaluate the clinical efficacy and side effects of combination of sodium ferulate and methycobal on diabetic peripheral neuropathy. Methods From January 2011 to February 2012, 60 patients with diabetic peripheral neuropathy were randomly divided into observation group (30 cases) and control group (30 cases). In the observation group, 300 mg of sodium ferulate was dissolved in 250 mL of physiological saline, administered by intravenous drip, 500 μg of miconazole was administered again, once per day by intramuscular injection, and 500 μg of the drug alone Can be guaranteed, administered by intramuscular injection, 1 / d, treatment of two courses were a course of 2 weeks. Results After 14 days of administration, 15 cases were markedly effective in observation group, 13 cases were effective and 2 cases were ineffective. In control group, 7 cases were markedly effective, 10 cases were effective and 13 cases were ineffective. The total effective rate in the two groups was statistically significant (uc = 9.72, P <0.01), with statistical significance. There were 2 cases of local vascular irritation in the observation group, mild dizziness in 1 case and mild symptoms in the control group, and none of the 3 cases had any effect on the further treatment and observation . Conclusions The combination of sodium ferulate and methycobal can effectively improve the symptoms of diabetic peripheral neuropathy. The method is safe and effective and should be widely applied clinically.