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以酚妥拉明及新斯的明为工具药， 从鼠侧脑室注入盐酸乌苏里藜芦碱（Ｖｅｒａ － Ｕ， ３μｇ·ｋｇ－ １） 研究其中枢降压机制。实验表明： 侧脑室注入Ｖｅｒａ － Ｕ可显著降低肾性高血压大鼠的血压， 其降压作用可被侧脑室预先注入的α受体阻断剂酚妥拉明完全阻断； 侧脑室注入胆碱酯酶抑制剂后， 肾性高血压大鼠血压明显升高， 新斯的明升高血压作用不受预先注入的Ｖｅｒａ－ Ｕ 的影响。结果提示： Ｖｅｒａ － Ｕ侧脑室注射对肾性高血压大鼠具有迅速而显著的降压作用； 其中枢机制在降压过程中发挥重要作用： 中枢α受体参与介导了Ｖｅｒａ － Ｕ 对肾性高血压大鼠的降压作用。
Using phentolamine and neostigmine as vehicle drugs, Wusu-U (3 μg·kg-1) was injected from the lateral ventricle of rats to study its central hypotensive mechanism. Experiments show that: Injection of Vera-U into the lateral ventricle can significantly reduce blood pressure in renal hypertensive rats, and its antihypertensive effect can be completely blocked by phentolamine, an alpha-blocker pre-infused into the lateral ventricle; After basic aldosterase inhibitors, the blood pressure of renal hypertension rats was significantly increased, and the neostigmine effect of neostigmine was not affected by pre-infused Vera-U. The results suggest that: Vera-U lateral ventricle injection has a rapid and significant antihypertensive effect on renal hypertensive rats; pivotal mechanisms play an important role in blood pressure reduction process: central alpha receptor involved in the mediation of Vera-U on the kidney Hypotensive effect of hypertensive rats.