目的 :研制双氯芬酸钠脂质体凝胶 ,并进行评价。方法 :运用薄膜蒸发法制备了双氯芬酸钠脂质体 ,然后用卡波姆 (Carbopol)为基质制得凝胶。并建立了一阶导数紫外分光光度法进行测定。结果 :测得样品低、中、高 3个浓度的平均回收率分别为 (10 1 1± 0 86 ) % ,(99 90± 1 0 4 ) %和 (10 0 5± 0 91) %。脂质体经凝胶柱分离后测得平均包封率为 4 3 6 % ,经库尔特计数器测得平均粒径为 1 37μm。凝胶分别于冰箱 (4℃ )和室温下密封保存 0 5、1、3、6mo ,6mo后的包封率下降分别为 4 4 %、6 8%。结论 :经初步评价 ,将双氯芬酸钠制成脂质体凝胶剂是可行的 Objective: To develop Diclofenac sodium liposome gel and evaluate it. METHODS: Diclofenac sodium liposomes were prepared by the thin film evaporation method and then gelled with Carbopol. And the first derivative UV spectrophotometry was established. Results: The average recoveries of the three samples at low, middle and high concentrations were (10 1 1 ± 0 86)%, (99 90 ± 1 0 4)% and (105 0 91)%, respectively. The average entrapment efficiency of the liposomes after separation by gel column was 436%, and the mean particle size was 137μm by Coulter counter. The gels were stored for 0 5, 1, 3 and 6mo in refrigerator (4 ℃) and room temperature, respectively, and the entrapment efficiency decreased by 44% and 68% respectively after 6 months. CONCLUSIONS: After preliminary evaluation, it is feasible to make diclofenac sodium liposome gel